2-Universal Positive Definite Integral Quinary Diagonal by Kim B. M. PDF

By Kim B. M.

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Rowe, and A. Meister, Biochemistry 8, 2681 (1969). [3] GLUTATHIONE BIOSYNTHESIS AND ITS INHIBITION 29 mine synthetase, n Administration of methionine sulfoximine to experimental animals leads to a decrease in the synthesis of glutamine and also that of GSH. Although such inhibition of GSH synthesis is effective, the usefulness of methionine sulfoximine in experimental studies is limited because it produces convulsions and has lethal effects that appear to be related to the inactivation of brain glutamine synthetase.

A. 87, 7185 (1990). 14 A. Meister, Pharmacol. Ther. 51, 155 (1991). 15 O. W. Griffith, in "Glutathione Centennial: Molecular Perspectives and Clinical Implications" (N. Taniguchi, T. Higashi, Y. Sakamoto, and A. ), Chap. 20, p. 285. Academic Press, New York, 1989. 30 6LUTATHIONE [41 transported. 16 Inhibition of GSH synthesis by administration of BSO is currently under study for treatment of drug- and radiation-resistant tumors (see Meister14). Several other compounds that inhibit y-glutamylcysteine synthetase in vitro have been studied including cystamine, L- and D-3-amino-l-chloro-2pentanone, and L-2-amino-4-oxo-5-chloropentanoate (see Seelig and Meisterl), y-Methylene D-glutamate inactivates the enzyme by binding to an active-site thiol.

Within, and H. Cohen, Arch. Biochem. Biophys. 256, 677 (1987). 17 F. F. Chu, J. H. Doroshow, and S. Esworthy, J. Biol. Chem. 268, 2571 (1993). 18 M. J. Berry, L. Banu, and P. R. Larsen, Nature (London) 349, 438 (1991). 19 K. E. Hill, R. S. -G. Yang, R. Read, and R. F. Burk, J. Biol. Chem. 266,10050 (1991). 20 R. Schuckelt, R. Brigelius-Floh6, M. Maiorino, A. Roveri, J. Reumkens, W. Strassburger, F. Ursini, B. Wolf, and L. Floh6, Free Radical Res. Commun. 14, 343 (1991). 21 R. Brigelius-Floh6, K.

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2-Universal Positive Definite Integral Quinary Diagonal Quadratic Forms by Kim B. M.


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